Azelastine  Impurity 29 CAS 1859-33-2 (free base)

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1859-33-2 (free base)
Molecular FormulaC7H13NO
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Azelastine  Impurity 29 CAS 1859-33-2 (free base) chemical structure

Description

The molecular framework of Azelastine  Impurity 29 (C7H13NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Azelastine  Impurity 29 (CAS 1859-33-2 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C7H13NOHCl and a molecular weight of 163.65 g/mol.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC7H13NO HCl
Molecular Weight163.65 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)1.0
Halogen ContentCl-containing
Nitrogen Atoms1

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